Title : Polychlorinated dibenzofurans (PCDFs): correlation between in vivo and in vitro structure-activity relationships.

Pub. Date : 1985 Oct

PMID : 3933143






1 Functional Relationships(s)
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1 Fifteen polychlorinated dibenzofuran (PCDF) congeners were administered in a dose-response fashion to immature male Wistar rats and ED50 values for body weight loss, thymic atrophy and the induction of the hepatic microsomal cytochrome P-448-dependent monooxygenases, aryl hydrocarbon hydroxylase (AHH) and 4-chlorobiphenyl hydroxylase were determined. Dibenzofurans, Polychlorinated cytochrome P450, family 1, subfamily a, polypeptide 2 Rattus norvegicus