Title : Inhibition of human and canine diamine oxidase by drugs used in an intensive care unit: relevance for clinical side effects?

Pub. Date : 1985 Apr

PMID : 3925736






1 Functional Relationships(s)
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1 Similarly with the cephalosporines, cefotiame and cefuroxime caused a marked inhibition of the human DAO activity, whereas another regularly-used substance of this class, cefotaxime, inhibited neither the human nor the canine enzyme in concentrations up to 10(-3) M. The observation that within a given therapeutic group some members inhibit and others do not, could be useful in choosing a therapy concept which minimizes the risk of a more severe "histamine" reaction in seriously ill patients. Cefuroxime amine oxidase copper containing 1 Homo sapiens