Title : Modification of histidines in human prothrombin. Effect on the interaction of fibrinogen with thrombin from diethyl pyrocarbonate-modified prothrombin.

Pub. Date : 1985 Apr 25

PMID : 3886645






2 Functional Relationships(s)
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1 Effect on the interaction of fibrinogen with thrombin from diethyl pyrocarbonate-modified prothrombin. Diethyl Pyrocarbonate fibrinogen beta chain Homo sapiens
2 Diethyl pyrocarbonate inactivated the potential fibrinogen-clotting activity of prothrombin with a second-order rate constant of 70 M-1 min-1 at pH 6.0 and 25 degrees C. The difference spectrum of the modified protein had a maximum absorption at 240 nm which is characteristic of N-carbethoxyhistidine. Diethyl Pyrocarbonate fibrinogen beta chain Homo sapiens