| Protein Name | fibrinogen beta chain |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 2244 |
| Gene Symbol | FGB |
| UniProt | P02675 (FIBB_HUMAN), V9HVY1 (V9HVY1_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
1774
Total Number of Articles : 4105 |
Description |
fibrinogen beta chain |
| Gene Summary |
The protein encoded by this gene is the beta component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Fibrinogen serves key roles in hemostasis and antimicrobial host defense. Mutations in this gene lead to several disorders, including afibrinogenemia, dysfibrinogenemia, hypodysfibrinogenemia and thrombotic tendency. [provided by RefSeq, Aug 2020] |
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| Properties | |