Title : Parkinsonism-inducing neurotoxin, N-methyl-4-phenyl-1,2,3,6 -tetrahydropyridine: uptake of the metabolite N-methyl-4-phenylpyridine by dopamine neurons explains selective toxicity.

Pub. Date : 1985 Apr

PMID : 3872460






2 Functional Relationships(s)
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1 N-Methyl-4-phenylpyridine (MPP+), a metabolite of MPTP formed by monoamine oxidase B, is accumulated into striatal and cerebral cortical synaptosomes by the dopamine and norepinephrine uptake systems, respectively, whereas MPTP itself is not accumulated. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine monoamine oxidase B Rattus norvegicus
2 N-Methyl-4-phenylpyridine (MPP+), a metabolite of MPTP formed by monoamine oxidase B, is accumulated into striatal and cerebral cortical synaptosomes by the dopamine and norepinephrine uptake systems, respectively, whereas MPTP itself is not accumulated. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine monoamine oxidase B Rattus norvegicus