Pub. Date : 1985 Feb 25
PMID : 3844406
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The formation and release of an eukaryotic initiation factor (eIF)-2 X GDP binary complex during eIF-5-mediated assembly of an 80 S ribosomal polypeptide chain initiation complex have been studied by sucrose gradient centrifugation analysis. | Guanosine Diphosphate | eukaryotic translation initiation factor 5 | Homo sapiens |
| 2 | Isolated 40 S initiation complex reacts with eIF-5 and 60 S ribosomal subunits to form an 80 S ribosomal initiation complex with concomitant hydrolysis of an equimolar amount of bound GTP to GDP and Pi. | Guanosine Diphosphate | eukaryotic translation initiation factor 5 | Homo sapiens |
| 3 | Evidence is presented that eIF-5-mediated hydrolysis releases the GTP bound to the 40 S initiation complex as an intact eIF-2 X GDP complex rather than as free GDP and eIF-2 which subsequently recombine to form the binary complex. | Guanosine Diphosphate | eukaryotic translation initiation factor 5 | Homo sapiens |
| 4 | Evidence is presented that eIF-5-mediated hydrolysis releases the GTP bound to the 40 S initiation complex as an intact eIF-2 X GDP complex rather than as free GDP and eIF-2 which subsequently recombine to form the binary complex. | Guanosine Diphosphate | eukaryotic translation initiation factor 5 | Homo sapiens |
| 5 | Furthermore, formation and release of eIF-2 X GDP from the ribosomal complex do not require concomitant formation of an 80 S initiation complex since both reactions occur efficiently when the 40 S initiation complex reacts with eIF-5 in the absence of 60 S ribosomal subunits. | Guanosine Diphosphate | eukaryotic translation initiation factor 5 | Homo sapiens |