Pub. Date : 1987 Jan 1
PMID : 3791215
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Endocrine therapy for advanced carcinoma of the breast: relationship between the effect of tamoxifen upon concentrations of progesterone receptor and subsequent response to treatment. | Tamoxifen | progesterone receptor | Homo sapiens |
| 2 | In some cell lines and tumors of mammary origin, tamoxifen causes an increase of progesterone receptor (PR) as a result of its partial estrogen agonist activity. | Tamoxifen | progesterone receptor | Homo sapiens |
| 3 | In some cell lines and tumors of mammary origin, tamoxifen causes an increase of progesterone receptor (PR) as a result of its partial estrogen agonist activity. | Tamoxifen | progesterone receptor | Homo sapiens |
| 4 | In this study we have assessed the effect of tamoxifen on PR in patients with advanced carcinoma of the breast in order to test if those with a rise in PR are more likely to respond to endocrine therapy. | Tamoxifen | progesterone receptor | Homo sapiens |
| 5 | In this study we have assessed the effect of tamoxifen on PR in patients with advanced carcinoma of the breast in order to test if those with a rise in PR are more likely to respond to endocrine therapy. | Tamoxifen | progesterone receptor | Homo sapiens |
| 6 | The controls without tamoxifen showed a marked variation in the level of PR in the first and second biopsies, suggesting heterogeneity of PR across the tumors studied. | Tamoxifen | progesterone receptor | Homo sapiens |
| 7 | However, the PR level was significantly higher in the second biopsy in the controls given tamoxifen and in the test group compared with those with no intervening treatment (p = 0.031). | Tamoxifen | progesterone receptor | Homo sapiens |
| 8 | This study indicates that some effect of tamoxifen upon PR can be demonstrated in human mammary tumors in vivo and that, by taking a second biopsy for PR estimation during treatment with tamoxifen, a more precise indication of subsequent response is obtained. | Tamoxifen | progesterone receptor | Homo sapiens |
| 9 | This study indicates that some effect of tamoxifen upon PR can be demonstrated in human mammary tumors in vivo and that, by taking a second biopsy for PR estimation during treatment with tamoxifen, a more precise indication of subsequent response is obtained. | Tamoxifen | progesterone receptor | Homo sapiens |