Title : Regioselectivity of catechol O-methyltransferase. The effect of pH on the site of O-methylation of fluorinated norepinephrines.

Pub. Date : 1986 Jan 5

PMID : 3753600






2 Functional Relationships(s)
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1 Selectivity of catechol O-methyltransferase has been examined for the three ring-fluorinated norepinephrines to elucidate the role of acidity of the phenolic groups in their methylation. Norepinephrine catechol-O-methyltransferase Homo sapiens
2 Substitution of fluorine at the 5-position of norepinephrine reverses the selectivity of catechol O-methyltransferase so that p-O-methylation predominates. Norepinephrine catechol-O-methyltransferase Homo sapiens