Pub. Date : 1987 Nov 16
PMID : 3683076
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The intracellular calcium antagonist, TMB-8, inhibits prolactin gene expression in GH3 cells. | 8-(N,N-diethylamino)octyl-3,4,5-trimethoxybenzoate | prolactin | Rattus norvegicus |
| 2 | We examined the effects of the drug, TMB-8, which promotes sequestration of intracellular Ca2+, on the ability of extracellular Ca2+ to stimulate prolactin gene expression in GH3 cells. | 8-(N,N-diethylamino)octyl-3,4,5-trimethoxybenzoate | prolactin | Rattus norvegicus |
| 3 | TMB-8 inhibited prolactin mRNA levels in a dose-dependent manner in the concentration range of 2.5-10 microM. | 8-(N,N-diethylamino)octyl-3,4,5-trimethoxybenzoate | prolactin | Rattus norvegicus |
| 4 | Both TMB-8 and the calmodulin inhibitor, calmidazolium, reversed the effects of Ca2+ on prolactin mRNA levels in cells that had been pretreated for 2 days with 0.4 mM CaCl2. | 8-(N,N-diethylamino)octyl-3,4,5-trimethoxybenzoate | prolactin | Rattus norvegicus |