Title : Dantrolene and mepacrine antagonize the hemolysis of human red blood cells by halothane and bee venom phospholipase A2.

Pub. Date : 1987 Sep 30

PMID : 3660410






3 Functional Relationships(s)
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1 Halothane addition caused 100% hydrolysis of all diacylphosphoglycerides by phospholipase A2, suggesting a mutual potentiation. Halothane phospholipase A2 group IB Homo sapiens
2 The major products of phospholipase A2 activity, arachidonic acid and lysophosphatidylcholine, when exogenously added, also greatly increased hemolysis induced by halothane, with arachidonic acid most closely resembling the synergism observed with phospholipase A2. Halothane phospholipase A2 group IB Homo sapiens
3 Dantrolene and mepacrine antagonized the synergism between halothane and phospholipase A2 most likely by reducing the lytic action of halothane in the presence of arachidonic acid. Halothane phospholipase A2 group IB Homo sapiens