Protein Name phospholipase A2 group IB
Organism Homo sapiens
Gene ID 5319
Gene Symbol


UniProt P04054 (PA21B_HUMAN)
Relationships Total Number of functionally related compound(s) : 1857
Total Number of Articles : 3347

phospholipase A2 group IB

Gene Summary

This gene encodes a secreted member of the phospholipase A2 (PLA2) class of enzymes, which is produced by the pancreatic acinar cells. The encoded calcium-dependent enzyme catalyzes the hydrolysis of the sn-2 position of membrane glycerophospholipids to release arachidonic acid (AA) and lysophospholipids. AA is subsequently converted by downstream metabolic enzymes to several bioactive lipophilic compounds (eicosanoids), including prostaglandins (PGs) and leukotrienes (LTs). The enzyme may be involved in several physiological processes including cell contraction, cell proliferation and pathological response. [provided by RefSeq, Aug 2013]

  • phospholipase A2
  • phosphatidylcholine 2-acylhydrolase 1B
  • phospholipase A2, group IB (pancreas)
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