Title : eIF-2B and the exchange of guanine nucleotides bound to eIF-2.

Pub. Date : 1987

PMID : 3647910






3 Functional Relationships(s)
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1 Two mechanisms have been considered--first a displacement reaction in which eIF-2B displaces GDP and GTP in a manner analogous to a "ping-pong" enzyme mechanism, and secondly the possibility that binding of eIF-2B to eIF-2 nucleotide complexes enhances the rate of nucleotide exchange without itself inducing nucleotide displacement. Guanosine Diphosphate eukaryotic translation initiation factor 2B subunit delta Homo sapiens
2 Two mechanisms have been considered--first a displacement reaction in which eIF-2B displaces GDP and GTP in a manner analogous to a "ping-pong" enzyme mechanism, and secondly the possibility that binding of eIF-2B to eIF-2 nucleotide complexes enhances the rate of nucleotide exchange without itself inducing nucleotide displacement. Guanosine Diphosphate eukaryotic translation initiation factor 2B subunit delta Homo sapiens
3 Minimum rate constants for the formation of eIF-2 X eIF-2B from eIF-2 X GDP and eIF-2 X GTP and reverse reactions are derived. Guanosine Diphosphate eukaryotic translation initiation factor 2B subunit delta Homo sapiens