Pub. Date : 1987 Sep 5
PMID : 3624250
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We now report that when protein synthesis is inhibited in mouse peritoneal macrophages by treatment with cycloheximide, puromycin, or actinomycin D, native LDL-induced whole-cell ACAT activity and CE accumulation is 10-fold higher than that seen in LDL-treated control cells. | Cycloheximide | acetyl-Coenzyme A acetyltransferase 1 | Mus musculus |
| 2 | The enhancement of ACAT activity was seen 4 h after the addition of cycloheximide, and ACAT activity returned to control values 4 h after the withdrawal of cycloheximide. | Cycloheximide | acetyl-Coenzyme A acetyltransferase 1 | Mus musculus |
| 3 | The enhancement of ACAT activity was seen 4 h after the addition of cycloheximide, and ACAT activity returned to control values 4 h after the withdrawal of cycloheximide. | Cycloheximide | acetyl-Coenzyme A acetyltransferase 1 | Mus musculus |
| 4 | Postnuclear supernatants and microsomes from cycloheximide-treated mouse peritoneal macrophages also had higher ACAT activity than microsomes from control cells, but the relative enhancement (maximum 3.3-fold) was less than that seen when ACAT was assayed in the intact cell. | Cycloheximide | acetyl-Coenzyme A acetyltransferase 1 | Mus musculus |
| 5 | Postnuclear supernatants and microsomes from cycloheximide-treated mouse peritoneal macrophages also had higher ACAT activity than microsomes from control cells, but the relative enhancement (maximum 3.3-fold) was less than that seen when ACAT was assayed in the intact cell. | Cycloheximide | acetyl-Coenzyme A acetyltransferase 1 | Mus musculus |
| 6 | In contrast to the situation with mouse peritoneal macrophages, cycloheximide treatment of J774 macrophages, which under normal conditions display high ACAT activity and CE accumulation in the presence of native LDL, did not result in further enhancement of either ACAT activity or LDL-induced CE accumulation. | Cycloheximide | acetyl-Coenzyme A acetyltransferase 1 | Mus musculus |