Title : Human liver folylpolyglutamate synthetase: biochemical characterization and interactions with folates and folate antagonists.

Pub. Date : 1987 Aug 1

PMID : 3619447






1 Functional Relationships(s)
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1 Comparison of MTX with its higher polyglutamates (MTX-Glu2 to MTX-Glu6) as FPGS substrates indicated a significant decrease in Vmax values with increasing glutamate chain length which was partially compensated for by a corresponding decrease in Km. Polyglutamic Acid folylpolyglutamate synthase Homo sapiens