Title : Novel Azine Linked Hybrids of 2-Indolinone and Thiazolodinone Scaffolds as CDK2 Inhibitors with Potential Anticancer Activity: In Silico Design, Synthesis, Biological, Molecular Dynamics and Binding Free Energy Studies.

Pub. Date : 2022 Sep

PMID : 35623140






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Docking studies in the active site of CDK2, one of the key checkpoints enzymes, revealed that the binding scores of the designed molecules are comparable to the reference enzyme"s inhibitors Sunitinib, Nintedanib, and Semaxanib. nintedanib cyclin dependent kinase 2 Homo sapiens