Title : AZD5305 More Tolerable than 1st-Generation PARP Inhibitors.

Pub. Date : 2022 May 26

PMID : 35616497






1 Functional Relationships(s)
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1 Findings from the phase I/IIa trial of AZD5305, a next-generation, highly selective PARP1 inhibitor, indicate that the drug is better tolerated in patients with ovarian, HER2-negative breast, pancreatic, and prostate cancers with BRCA1/2, PALB2, and RAD51C mutations compared with first-generation PARP inhibitors. AZD5305 partner and localizer of BRCA2 Homo sapiens