PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 35616497-1 2022 Findings from the phase I/IIa trial of AZD5305, a next-generation, highly selective PARP1 inhibitor, indicate that the drug is better tolerated in patients with ovarian, HER2-negative breast, pancreatic, and prostate cancers with BRCA1/2, PALB2, and RAD51C mutations compared with first-generation PARP inhibitors. AZD5305 39-46 partner and localizer of BRCA2 Homo sapiens 239-244