Pub. Date : 2022 May 26
PMID : 35616339
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The circadian metabolite, NAD+ , serves as a crucial link connecting clock genes to sirtuin activity. | NAD | clock circadian regulator | Homo sapiens |
| 2 | This is because, NAMPT which is a rate limiting enzyme in NAD+ biosynthesis is transcriptionally regulated by the clock genes and NAD+ in turn is a cofactor regulating the deacetylation activity of sirtuins. | NAD | clock circadian regulator | Homo sapiens |
| 3 | This is because, NAMPT which is a rate limiting enzyme in NAD+ biosynthesis is transcriptionally regulated by the clock genes and NAD+ in turn is a cofactor regulating the deacetylation activity of sirtuins. | NAD | clock circadian regulator | Homo sapiens |
| 4 | Thus, the Clock-NAD+-Sirtuin connection represents a novel "feedback loop" circuit that regulates the metabolic machinery. | NAD | clock circadian regulator | Homo sapiens |
| 5 | The current review underpins the importance of NAD+ on the sirtuin and clock connection in preventing fatty liver disorder. | NAD | clock circadian regulator | Homo sapiens |