Pub. Date : 2022
PMID : 35614939
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Furthermore, high-dose OCA induced cholesterol accumulation in livers via the upregulation of genes involved in cholesterol acquisition and downregulation of genes regulating cholesterol degradation in liver, leading to the production of interleukin -1beta and an FXR-mediated inflammatory response. | obeticholic acid | interleukin 1 beta | Mus musculus |
| 2 | Conclusion: The high-dose OCA induced FXR-dependent hepatic injury via cholesterol accumulation and interleukin -1beta pathway in the NAFLD mice. | obeticholic acid | interleukin 1 beta | Mus musculus |