PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 35614939-7 2022 Furthermore, high-dose OCA induced cholesterol accumulation in livers via the upregulation of genes involved in cholesterol acquisition and downregulation of genes regulating cholesterol degradation in liver, leading to the production of interleukin -1beta and an FXR-mediated inflammatory response. obeticholic acid 23-26 interleukin 1 beta Mus musculus 238-256 35614939-8 2022 Conclusion: The high-dose OCA induced FXR-dependent hepatic injury via cholesterol accumulation and interleukin -1beta pathway in the NAFLD mice. obeticholic acid 26-29 interleukin 1 beta Mus musculus 100-118