PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
35614939-1	2022	Objective: Obeticholic acid (OCA), a potent farnesoid X receptor (FXR) agonist, is a promising drug for nonalcoholic fatty liver disease (NAFLD); however, it can cause liver injury, especially at high doses.	obeticholic acid	11-27	nuclear receptor subfamily 1, group H, member 4	Mus musculus	44-64	
35614939-1	2022	Objective: Obeticholic acid (OCA), a potent farnesoid X receptor (FXR) agonist, is a promising drug for nonalcoholic fatty liver disease (NAFLD); however, it can cause liver injury, especially at high doses.	obeticholic acid	11-27	nuclear receptor subfamily 1, group H, member 4	Mus musculus	66-69	
35614939-1	2022	Objective: Obeticholic acid (OCA), a potent farnesoid X receptor (FXR) agonist, is a promising drug for nonalcoholic fatty liver disease (NAFLD); however, it can cause liver injury, especially at high doses.	obeticholic acid	29-32	nuclear receptor subfamily 1, group H, member 4	Mus musculus	44-64	
35614939-1	2022	Objective: Obeticholic acid (OCA), a potent farnesoid X receptor (FXR) agonist, is a promising drug for nonalcoholic fatty liver disease (NAFLD); however, it can cause liver injury, especially at high doses.	obeticholic acid	29-32	nuclear receptor subfamily 1, group H, member 4	Mus musculus	66-69	
35614939-3	2022	Methods: Wild-type (WT) mice and FXR-/- mice were administered with over-dose OCA (0.40%) and high-dose OCA (0.16%), in a high-fat diet.	obeticholic acid	78-81	nuclear receptor subfamily 1, group H, member 4	Mus musculus	33-36	
35614939-6	2022	High-dose OCA caused hepatic stellate cell activation and liver fibrosis in the presence of FXR.	obeticholic acid	10-13	nuclear receptor subfamily 1, group H, member 4	Mus musculus	92-95	
35614939-7	2022	Furthermore, high-dose OCA induced cholesterol accumulation in livers via the upregulation of genes involved in cholesterol acquisition and downregulation of genes regulating cholesterol degradation in liver, leading to the production of interleukin -1beta and an FXR-mediated inflammatory response.	obeticholic acid	23-26	nuclear receptor subfamily 1, group H, member 4	Mus musculus	264-267	
35614939-8	2022	Conclusion: The high-dose OCA induced FXR-dependent hepatic injury via cholesterol accumulation and interleukin -1beta pathway in the NAFLD mice.	obeticholic acid	26-29	nuclear receptor subfamily 1, group H, member 4	Mus musculus	38-41