Pub. Date : 2022 May 20
PMID : 35605662
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Selective PPARdelta agonist seladelpar suppresses bile acid synthesis by reducing hepatocyte CYP7A1 via the fibroblast growth factor 21 signaling pathway. | Seladelpar | fibroblast growth factor 21 | Mus musculus |
| 2 | In addition, seladelpar upregulated fibroblast growth factor 21 (Fgf21) in mouse liver, serum, and in cultured hepatocytes. | Seladelpar | fibroblast growth factor 21 | Mus musculus |
| 3 | In addition, seladelpar upregulated fibroblast growth factor 21 (Fgf21) in mouse liver, serum, and in cultured hepatocytes. | Seladelpar | fibroblast growth factor 21 | Mus musculus |
| 4 | The suppressive effect of seladelpar on Cyp7a1 expression was blocked by a JNK inhibitor as well as in the absence of Fgf21, indicating that Fgf21 plays an indispensable role in PPARdelta-mediated downregulation of Cyp7a1. | Seladelpar | fibroblast growth factor 21 | Mus musculus |