Title : Selective PPARĪ“ agonist seladelpar suppresses bile acid synthesis by reducing hepatocyte CYP7A1 via the fibroblast growth factor 21 signaling pathway.

Pub. Date : 2022 May 20

PMID : 35605662






2 Functional Relationships(s)
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1 The suppressive effect of seladelpar on Cyp7a1 expression was blocked by a JNK inhibitor as well as in the absence of Fgf21, indicating that Fgf21 plays an indispensable role in PPARdelta-mediated downregulation of Cyp7a1. Seladelpar mitogen-activated protein kinase 8 Mus musculus
2 In conclusion, we show that seladelpar reduces bile acid synthesis via an FGF21-dependent mechanism that signals at least partially through JNK to repress CYP7A1. Seladelpar mitogen-activated protein kinase 8 Mus musculus