Title : HMGB1-NLRP3-P2X7R pathway participates in PM2.5-induced hippocampal neuron impairment by regulating microglia activation.

Pub. Date : 2022 May 20

PMID : 35605331






1 Functional Relationships(s)
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1 Therefore, we further studied how hippocampal neurons affected microglia under PM2.5 exposure, Further investigation indicated that silencing HMGB1 could affect the activation of P2X7R and reduce the release of ATP from hippocampal neurons, thus protecting the interaction between microglia and hippocampal neurons. Adenosine Triphosphate high mobility group box 1 Homo sapiens