Pub. Date : 2022 May 23
PMID : 35605218
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Dexmedetomidine Leads to the Mitigation of Myocardial Ischemia/Reperfusion-Induced Acute Lung Injury in Diabetic Rats Via Modulation of Hypoxia-Inducible Factor-1alpha. | Dexmedetomidine | hypoxia inducible factor 1 subunit alpha | Rattus norvegicus |
| 2 | INTRODUCTION: The objective of this study is to investigate the protective mechanism of dexmedetomidine (Dex) in myocardial ischemia/reperfusion (MIR)-induced acute lung injury (ALI) of diabetic rats by inhibiting hypoxia-inducible factor-1alpha (HIF-1alpha). | Dexmedetomidine | hypoxia inducible factor 1 subunit alpha | Rattus norvegicus |
| 3 | INTRODUCTION: The objective of this study is to investigate the protective mechanism of dexmedetomidine (Dex) in myocardial ischemia/reperfusion (MIR)-induced acute lung injury (ALI) of diabetic rats by inhibiting hypoxia-inducible factor-1alpha (HIF-1alpha). | Dexmedetomidine | hypoxia inducible factor 1 subunit alpha | Rattus norvegicus |
| 4 | INTRODUCTION: The objective of this study is to investigate the protective mechanism of dexmedetomidine (Dex) in myocardial ischemia/reperfusion (MIR)-induced acute lung injury (ALI) of diabetic rats by inhibiting hypoxia-inducible factor-1alpha (HIF-1alpha). | Dexmedetomidine | hypoxia inducible factor 1 subunit alpha | Rattus norvegicus |
| 5 | INTRODUCTION: The objective of this study is to investigate the protective mechanism of dexmedetomidine (Dex) in myocardial ischemia/reperfusion (MIR)-induced acute lung injury (ALI) of diabetic rats by inhibiting hypoxia-inducible factor-1alpha (HIF-1alpha). | Dexmedetomidine | hypoxia inducible factor 1 subunit alpha | Rattus norvegicus |
| 6 | Besides, Dex could also inhibit HIF-1alpha expression. | Dexmedetomidine | hypoxia inducible factor 1 subunit alpha | Rattus norvegicus |
| 7 | Moreover, Dex + LV-HIF-1alpha reversed the protective role of Dex on diabetic MIR-induced ALI. | Dexmedetomidine | hypoxia inducible factor 1 subunit alpha | Rattus norvegicus |
| 8 | CONCLUSION: Our study has made it clear that Dex inhibited the upregulation of HIF-1alpha in diabetic MIR-induced ALI, and thus protect lung functions by quenching the accumulation of oxygen radical and reducing lung inflammatory response. | Dexmedetomidine | hypoxia inducible factor 1 subunit alpha | Rattus norvegicus |