Title : Roxadustat promotes osteoblast differentiation and prevents estrogen deficiency-induced bone loss by stabilizing HIF-1α and activating the Wnt/β-catenin signaling pathway.

Pub. Date : 2022 May 21

PMID : 35597989






4 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Roxadustat promotes osteoblast differentiation and prevents estrogen deficiency-induced bone loss by stabilizing HIF-1alpha and activating the Wnt/beta-catenin signaling pathway. roxadustat catenin beta 1 Rattus norvegicus
2 Roxadustat activated the HIF-1alpha and Wnt/beta-catenin pathways. roxadustat catenin beta 1 Rattus norvegicus
3 HIF-1alpha knockdown or Wnt/beta-catenin pathway inhibition significantly attenuated roxadustat-promoted osteoblast differentiation. roxadustat catenin beta 1 Rattus norvegicus
4 Roxadustat upregulated the protein expression levels of the osteogenic markers, HIF-1alpha and beta-catenin in the bone tissue of OVX rats. roxadustat catenin beta 1 Rattus norvegicus