Pub. Date : 2022 May 21
PMID : 35596723
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The HN1/HMGB1 axis promotes the proliferation and metastasis of hepatocellular carcinoma and attenuates the chemosensitivity to oxaliplatin. | Oxaliplatin | high mobility group box 1 | Homo sapiens |
| 2 | In the nucleus, downregulation of HMGB1 followed by HN1 knockdown resulted in increased DNA damage and cell death in the oxaliplatin-treated HCC cells. | Oxaliplatin | high mobility group box 1 | Homo sapiens |
| 3 | Furthermore, HN1 knockdown in combination with HMGB1 overexpression restored the aggressive phenotypes of HCC cells and sensitivity of these cells to oxaliplatin. | Oxaliplatin | high mobility group box 1 | Homo sapiens |