Title : Effects of arsenic on the topology and solubility of promyelocytic leukemia (PML)-nuclear bodies.

Pub. Date : 2022

PMID : 35594310






1 Functional Relationships(s)
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1 Trivalent arsenic (As3+) is known to cure APL by binding to cysteine residues of PML and enhance the degradation of PML-retinoic acid receptor alpha (RARalpha), a t(15;17) gene translocation product in APL cells, and restore PML-nuclear bodies (NBs). Cysteine PML nuclear body scaffold Homo sapiens