Title : Vinpocetine enhances cisplatin sensitivity of non-small cell lung cancer cells by reducing the nuclear factor erythroid 2-related factor 2 signaling.

Pub. Date : 2022 May 17

PMID : 35580917






4 Functional Relationships(s)
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Protein Name
Organism
1 Vinpocetine enhances cisplatin sensitivity of non-small cell lung cancer cells by reducing the nuclear factor erythroid 2-related factor 2 signaling. vinpocetine NFE2 like bZIP transcription factor 2 Homo sapiens
2 In addition, treatment with vinpocetine suppressed protein expression of Nrf2 and inhibited messenger RNA levels of heme oxygenase 1 and NAD(P)H dehydrogenase quinone 1 induced by cisplatin. vinpocetine NFE2 like bZIP transcription factor 2 Homo sapiens
3 Interestingly, the overexpression of Nrf2 abolished the antiproliferative effects of vinpocetine on NSCLC cells. vinpocetine NFE2 like bZIP transcription factor 2 Homo sapiens
4 Vinpocetine enhances cisplatin sensitivity of NSCLC cells in part by suppressing Nrf2 signaling. vinpocetine NFE2 like bZIP transcription factor 2 Homo sapiens