Pub. Date : 2022 May 16
PMID : 35578169
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Here we hypothesized that famotidine activates the inflammatory reflex, a brain-integrated vagus nerve mechanism which inhibits inflammation via alpha 7 nicotinic acetylcholine receptor (alpha7nAChR) signal transduction, to prevent cytokine storm. | Famotidine | cholinergic receptor, nicotinic, alpha polypeptide 7 | Mus musculus |
| 2 | Either bilateral sub-diaphragmatic vagotomy or genetic knock-out of alpha7nAChR abolished the anti-inflammatory effects of famotidine, indicating the inflammatory reflex as famotidine"s mechanism of action. | Famotidine | cholinergic receptor, nicotinic, alpha polypeptide 7 | Mus musculus |