Title : Inhibition of (Pro)renin Receptor-Mediated Oxidative Stress Alleviates Doxorubicin-Induced Heart Failure.

Pub. Date : 2022

PMID : 35574363






1 Functional Relationships(s)
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1 Significance: Our findings showed that PRR inhibition could weaken RAC1-NOX4 pathway and alleviate DOX-induced HF via decreasing ROS production, thereby suggesting a promising target for the treatment of DOX-induced HF. Reactive Oxygen Species Rac family small GTPase 1 Rattus norvegicus