Title : Effect of anti-iduronidase sulfatase in patients with Mucopolysaccharidosis type II treated with enzyme replacement therapy.

Pub. Date : 2022 May 11

PMID : 35568060






2 Functional Relationships(s)
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1 CONCLUSIONS: Patients with the neuronopathic form and lack of IDS protein expression were most at risk to develop sustained anti-IDS titers, which inhibited IDS uptake and/or activity in vitro, and the efficacy of ERT in patients by lowering urinary glycosaminoglycan levels. Glycosaminoglycans iduronate 2-sulfatase Homo sapiens
2 CONCLUSIONS: Patients with the neuronopathic form and lack of IDS protein expression were most at risk to develop sustained anti-IDS titers, which inhibited IDS uptake and/or activity in vitro, and the efficacy of ERT in patients by lowering urinary glycosaminoglycan levels. Glycosaminoglycans iduronate 2-sulfatase Homo sapiens