Pub. Date : 2022 Jul 20
PMID : 35567995
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | ACSL4 promotes colorectal cancer and is a potential therapeutic target of emodin. | Emodin | acyl-CoA synthetase long chain family member 4 | Homo sapiens |
| 2 | A docking simulation assay and an MST assay were performed to explore the potential mode of emodin binding to ACSL4. | Emodin | acyl-CoA synthetase long chain family member 4 | Homo sapiens |
| 3 | Docking simulation and MST assay confirmed that emodin can directly bind to ACSL4 target. | Emodin | acyl-CoA synthetase long chain family member 4 | Homo sapiens |
| 4 | Moreover, ACSL4 overexpression abolished the inhibitory effect of emodin on VEGF secretion and VEGFR1 and VEGFR2 expression, but VEGFR1 and VEGFR2 overexpression did not affect the inhibitory effect of emodin on ACSL4 expression and VEGF secretion. | Emodin | acyl-CoA synthetase long chain family member 4 | Homo sapiens |
| 5 | Moreover, ACSL4 overexpression abolished the inhibitory effect of emodin on VEGF secretion and VEGFR1 and VEGFR2 expression, but VEGFR1 and VEGFR2 overexpression did not affect the inhibitory effect of emodin on ACSL4 expression and VEGF secretion. | Emodin | acyl-CoA synthetase long chain family member 4 | Homo sapiens |
| 6 | Moreover, ACSL4 overexpression abolished the inhibitory effect of emodin on VEGF secretion and VEGFR1 and VEGFR2 expression, but VEGFR1 and VEGFR2 overexpression did not affect the inhibitory effect of emodin on ACSL4 expression and VEGF secretion. | Emodin | acyl-CoA synthetase long chain family member 4 | Homo sapiens |