Protein Name acyl-CoA synthetase long chain family member 4
Organism Homo sapiens
Gene ID 2182
Gene Symbol


UniProt O60488 (ACSL4_HUMAN), Q8TAF6 (Q8TAF6_HUMAN)
Relationships Total Number of functionally related compound(s) : 112
Total Number of Articles : 118

acyl-CoA synthetase long chain family member 4

Gene Summary

The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme preferentially utilizes arachidonate as substrate. The absence of this enzyme may contribute to the cognitive disability or Alport syndrome. Alternative splicing of this gene generates multiple transcript variants. [provided by RefSeq, Jan 2016]

  • long-chain-fatty-acid--CoA ligase 4
  • acyl-CoA synthetase 4
  • arachidonate--CoA ligase
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