Title : A Novel Mechanism for SIRT1 Activators That Does Not Rely on the Chemical Moiety Immediately C-Terminal to the Acetyl-Lysine of the Substrate.

Pub. Date : 2022 Apr 22

PMID : 35566069






1 Functional Relationships(s)
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Protein Name
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1 The longer distance between the anomeric C1" carbon of the ribose ring in OAADPr and Arg274 of SIRT1 (a conserved residue among sirtuins) than that between the anomeric C1" carbon in OAADPr and the Arg of SIRT2, SIRT3, SIRT5, and SIRT6, should be responsible for the high selectivity of CWR for SIRT1. Ribose sirtuin 2 Homo sapiens