Protein Name sirtuin 2
Organism Homo sapiens
Gene ID 22933
Gene Symbol


UniProt Q8IXJ6 (SIR2_HUMAN), A0A024R0G8 (A0A024R0G8_HUMAN), A0A0A0MRF5 (A0A0A0MRF5_HUMAN)
Relationships Total Number of functionally related compound(s) : 288
Total Number of Articles : 368

sirtuin 2

Gene Summary

This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Several transcript variants are resulted from alternative splicing of this gene. [provided by RefSeq, Jul 2010]

  • NAD-dependent protein deacetylase sirtuin-2
  • NAD-dependent deacetylase sirtuin-2
  • NAD-dependent protein defatty-acylase sirtuin-2
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