Title : KRAS Mutations Impact Clinical Outcome in Metastatic Non-Small Cell Lung Cancer.

Pub. Date : 2022 Apr 20

PMID : 35565194






2 Functional Relationships(s)
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Protein Name
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1 When treated with first-line platinum doublet (n = 195), KRASMUT was a negative factor for survival (p = 0.018), with median OS of 9 months vs. KRASWT at 11 months. Platinum KRAS proto-oncogene, GTPase Homo sapiens
2 kRAS mutations are associated with better response to treatment with immune checkpoint blockade and worse response to platinum doublet chemotherapy as well as shorter general OS in Stage IV NSCLC. Platinum KRAS proto-oncogene, GTPase Homo sapiens