Title : Examination of the Impact of CYP3A4/5 on Drug-Drug Interaction between Schizandrol A/Schizandrol B and Tacrolimus (FK-506): A Physiologically Based Pharmacokinetic Modeling Approach.

Pub. Date : 2022 Apr 19

PMID : 35562875






1 Functional Relationships(s)
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1 Moreover, our PBPK model predicted that multiple doses of SZB would increase tacrolimus exposure by 26% and 57% in CYP3A5 expressers and non-expressers, respectively. Tacrolimus cytochrome P450 family 3 subfamily A member 5 Homo sapiens