Title : N6-methyladenosine regulated FGFR4 attenuates ferroptotic cell death in recalcitrant HER2-positive breast cancer.

Pub. Date : 2022 May 13

PMID : 35562334






1 Functional Relationships(s)
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1 Notably, suppression of FGFR4 dramatically diminishes glutathione synthesis and Fe2+ efflux efficiency via the beta-catenin/TCF4-SLC7A11/FPN1 axis, resulting in excessive ROS production and labile iron pool accumulation. Glutathione solute carrier family 7 member 11 Homo sapiens