Protein Name solute carrier family 7 member 11
Organism Homo sapiens
Gene ID 23657
Gene Symbol


Relationships Total Number of functionally related compound(s) : 219
Total Number of Articles : 395

solute carrier family 7 member 11

Gene Summary

This gene encodes a member of a heteromeric, sodium-independent, anionic amino acid transport system that is highly specific for cysteine and glutamate. In this system, designated Xc(-), the anionic form of cysteine is transported in exchange for glutamate. This protein has been identified as the predominant mediator of Kaposi sarcoma-associated herpesvirus fusion and entry permissiveness into cells. Also, increased expression of this gene in primary gliomas (compared to normal brain tissue) was associated with increased glutamate secretion via the XCT channels, resulting in neuronal cell death. [provided by RefSeq, Sep 2011]

  • cystine/glutamate transporter
  • amino acid transport system xc-
  • calcium channel blocker resistance protein CCBR1
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