Title : β-Klotho promotes glycolysis and glucose-stimulated insulin secretion via GP130.

Pub. Date : 2022 May

PMID : 35551509






1 Functional Relationships(s)
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1 Mechanistically, KLB interacts with and stabilizes the cytokine receptor subunit GP130 by blockage of ubiquitin-dependent lysosomal degradation, thereby facilitating interleukin-6-evoked STAT3-HIF1alpha signaling, which in turn transactivates a cluster of glycolytic genes for adenosine triphosphate production and GSIS. Adenosine interleukin 6 Mus musculus