Title : Priming of microglia by type II interferon is lasting and resistant to modulation by interleukin-10 in situ.

Pub. Date : 2022 Jul 15

PMID : 35537331






1 Functional Relationships(s)
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1 We report that serial exposure of hippocampal slice cultures to IFN-gamma and lipopolysaccharide (Toll-like receptor 4 ligand) induces high release of IL-6, TNF-alpha and nitric oxide, concomitant loss of electrical network activity (neuronal gamma oscillations) and neurodegeneration. Nitric Oxide interferon gamma Homo sapiens