Title : Cografting of Zwitterionic Sulfobetaines and Cationic Amines on β-Cyclodextrin-Threaded Polyrotaxanes Facilitates Cellular Association and Tissue Accumulation with High Biocompatibility.

Pub. Date : 2022 Jun 13

PMID : 35536230






2 Functional Relationships(s)
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1 beta-Cyclodextrins (beta-CDs) and beta-CD-containing polymers have attracted considerable attention as potential candidates for the treatment of cholesterol-related metabolic and intractable diseases. Cholesterol ACD shelterin complex subunit and telomerase recruitment factor Homo sapiens
2 Furthermore, partly betainized PRXs ameliorated the abnormal free cholesterol accumulation in Niemann-Pick type C disease patient-derived cells at lower concentrations than beta-CD derivatives and previously designed PRXs. Cholesterol ACD shelterin complex subunit and telomerase recruitment factor Homo sapiens