Title : Inhibition of Src but not Syk causes weak reversal of GPVI-mediated platelet aggregation measured by light transmission aggregometry.

Pub. Date : 2022 May 9

PMID : 35535424






2 Functional Relationships(s)
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1 The addition of inhibitors of Src, Syk or Bruton"s tyrosine kinase (Btk) at 150 sec, by which time aggregation was maximal, induced rapid loss of tyrosine phosphorylation of their downstream proteins, but only Src kinase inhibition caused a weak (~10%) reversal in light transmission. Tyrosine SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens
2 The addition of inhibitors of Src, Syk or Bruton"s tyrosine kinase (Btk) at 150 sec, by which time aggregation was maximal, induced rapid loss of tyrosine phosphorylation of their downstream proteins, but only Src kinase inhibition caused a weak (~10%) reversal in light transmission. Tyrosine SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens