Pub. Date : 2022 Apr
PMID : 35527375
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The study showed that a short-term exposure to GSNO for 3 h at 500 microM concentration caused increase in the concentration of peroxynitrite in Caco-2 cells, which reduced the activity, but not the amount of Pgp. | S-Nitrosoglutathione | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 2 | Increase in the duration of exposure to 24 h increased the amount and activity of Pgp at GSNO concentrations of 10 and 50 microM, increased the amount without increasing activity at 100 microM concentration, and decreased the amount of the transporter protein at 500 microM. | S-Nitrosoglutathione | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 3 | Duration of exposure to GSNO of 72 h at concentration of 10 microM resulted in the increase of the amount and activity of Pgp, while at concentration of 100 and 500 microM it decreased the amount of the transport protein. | S-Nitrosoglutathione | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 4 | At the same time, it was shown using specific inhibitors that the increase in the amount of Pgp under the influence of low concentrations of GSNO was realized through the NO-cGMP signaling pathway, and the effect of the higher concentration of GSNO and the respective development of nitrosative stress was realized through Nrf2 and the constitutive androstane receptor. | S-Nitrosoglutathione | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 5 | At the same time, it was shown using specific inhibitors that the increase in the amount of Pgp under the influence of low concentrations of GSNO was realized through the NO-cGMP signaling pathway, and the effect of the higher concentration of GSNO and the respective development of nitrosative stress was realized through Nrf2 and the constitutive androstane receptor. | S-Nitrosoglutathione | ATP binding cassette subfamily B member 1 | Homo sapiens |