Title : Evidence for a PI3-kinase independent pathway in the regulation of Rap1b activation downstream of the P2Y12 receptor in platelets.

Pub. Date : 2022 May 6

PMID : 35514261






2 Functional Relationships(s)
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1 Platelet activation by adenosine diphosphate (ADP) is mediated through two G-protein-coupled receptors, P2Y1 and P2Y12, which signal through Gq and Gi, respectively. Adenosine Diphosphate purinergic receptor P2Y12 Homo sapiens
2 These data suggest that ADP-induced Rap1b activation requires both P2Y1 and P2Y12. Adenosine Diphosphate purinergic receptor P2Y12 Homo sapiens