Title : Up-regulation of Nrf2/HO-1 and inhibition of TGF-β1/Smad2/3 signaling axis by daphnetin alleviates transverse aortic constriction-induced cardiac remodeling in mice.

Pub. Date : 2022 Jun

PMID : 35513128






2 Functional Relationships(s)
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1 Mechanistically, Daph alone treatment enhanced the protein levels of Nrf2, NQO1, and HO-1 in H9c2 cells. daphnetin heme oxygenase 1 Rattus norvegicus
2 Taken together, Daph effectively counteracted the TAC-induced cardiac hypertrophy and fibrosis by improving the Nrf2/HO-1 axis and inhibiting the TGF-beta1/Smad2/3 signaling axis. daphnetin heme oxygenase 1 Rattus norvegicus