Title : Gut-derived lipopolysaccharide promotes alcoholic hepatosteatosis and subsequent hepatocellular carcinoma by stimulating neutrophil extracellular traps through TLR4.

Pub. Date : 2022 May 4

PMID : 35508957






2 Functional Relationships(s)
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1 When mice lacking TLR4 received chronic alcohol feeding, intrahepatic markers of NETs formation decreased, and hepatosteatosis and HCC were alleviated. Alcohols toll-like receptor 4 Mus musculus
2 Conclusion: Formation of NETs following LPS stimulation of TLR4 upon chronic alcohol usage leads to increased alcoholic steatosis and subsequent HCC. Alcohols toll-like receptor 4 Mus musculus