Title : Design, synthesis, in silico docking, ADMET and anticancer evaluations of thiazolidine-2,4-diones bearing heterocyclic rings as dual VEGFR-2/EGFRT790M tyrosine kinase inhibitors.

Pub. Date : 2022 Apr 22

PMID : 35496328






1 Functional Relationships(s)
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1 Derivatives 5g, 4g and 4f were observed to be the highest effective derivatives that inhibited VEGFR-2 at the submicromolar level (IC50 = 0.080, 0.083 and 0.095 muM respectively) in comparison to sorafenib (IC50 = 0.084 muM). Sorafenib kinase insert domain receptor Homo sapiens