Title : Metformin and Thymoquinone Synergistically Inhibit Proliferation of Imatinib-Resistant Human Leukemic Cells.

Pub. Date : 2022

PMID : 35496297






1 Functional Relationships(s)
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1 A combination of 1.25 mM metformin and 0.625 microM TQ increased the levels of cleaved poly (ADP-ribose) polymerase (PARP), decreased the levels of proliferation regulatory proteins, and inhibited protein kinase B (Akt) and NF-kappaB signaling in primary CLL cells. Metformin AKT serine/threonine kinase 1 Homo sapiens